Biogenesis of Pore Architecture in Voltage-Gated K+ Channels
نویسندگان
چکیده
منابع مشابه
Biogenesis of the pore architecture of a voltage-gated potassium channel.
The pore domain of voltage-gated potassium (Kv) channels consists of transmembrane helices S5 and S6, the turret, the pore helix, the selectivity filter, and the loop preceding S6, with a tertiary reentrant structure between S5 and S6. Using biogenic intermediates, mass tagging (pegylation), and a molecular tape measure, we explored the possibility that the first stages of pore formation occur ...
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Voltage-dependent gating in K(+) channels results from the mechanical coupling of voltage sensor movements to pore opening. We used single and double mutations in the pore of the Shaker K(+) channel to analyze a late concerted pore opening transition and interpreted the results in the context of known K(+) channel structures. Gating sensitive mutations are located at mechanistically informative...
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Typical single channel recordings in voltage-dependent K channels show two simple conductance states: open or shut. Considering the fact that K channels are assembled with four identical subunits, the classical interpretation has been that the conduction pathway is not formed unless all four subunits are in their active positions. In fact, this agrees with the molecular interpretation of the op...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.637